A Boeing 777 arrives at JFK and is on its way across the tarmac, when it suddenly stops dead. All window shades are pulled down. All lights are out. All communication channels have gone quiet. Crews on the ground are lost for answers, but an alert goes out to the CDC. Dr. Eph Goodweather, head of their Canary project, a rapid-response team that investigates biological threats, gets the call and boards the plane. What he finds makes his blood run cold....

A ragtag network of humans--Eph, a brilliant scientist; Vasiliy Fet, an exterminator; and Gus, a former gangbanger--are determined to disrupt and destroy the vampire new world order.