The Patternist series, originally published from 1977-1984, details a secret history continuing into from the Ancient Egyptian period to the far future that involves telepathic mind control and an extraterrestrial plague. A profile of Butler in Black Women in America notes that the themes of the series include "racial and gender-based animosity, the ethical implications of biological engineering, the question of what it means to be human, ethical and unethical uses of power, and how the assumption of power changes people."--Wikipedia

Wild seed: Doro is an entity who changes bodies like clothes, killing his hosts by reflex -- or design. He fears no one -- until he meets Anyanwu. Anyanwu is a shapeshifter who can absorb bullets and heal with a kiss...and savage anyone who threatens those she loves. She fears no one -- until she meets Doro. From African jungles to the colonies of America, Doro and Anyanwu weave together a pattern of destiny that not even immortals can imagine

Mind of my mind: A young ghetto telepath launches a psychic struggle against the four-thousand-year-old immortal who has been her father, lover, master, and creator to free her fellow telepaths

Clay's ark: Asa Elias Doyle and her companions encounter an alien life form so destructive that they exile themselves to the desert to avoid contaminating others, but their compulsion to infect others is overwhelming and, in a desperate plea for help, kidnap a doctor and his two daughters

Patternmaster: A telepathic race is ruled by the strong mind of the Patternmaster, but his ruthless son craves the ultimate power of the position and has murdered everyone who stands in his way except a final victim--his younger brother